How to identify false information on estrogen safety?

There are plenty of false information about safety of estrogen.
Estrogen has been well documented to promote cancer by tens of thousands of scientific reports.
A recent study by scientists at Harvard Unversity provided new evidence indicating that estrogen not only promotes but also directly causes breast cancer. This new discovery further confirms the cancer risk associated with estrogen.  But, there is no shortage of information saying a certain type of estrogen is safe.
For example, a report says that "Using vaginal estrogen is not linked to high breast cancer risk."
Is it true?
Let us look at how many years the study took. The study was from 1993 to 1998. It is a relatively long clinical study for other diseases, but it is too short to test safety for cancer. Thus, the conclusion is false because one may not get cancer in 5 years, not even in 10 year. It often takes more than 20 years for cancer to develop. In fact, all estrogen or estrogen derivative drugs, even the ingested forms, have safety studies to back them up. They are all tested safe in both animals and humans. If they do not have safety data, these drugs cannot be sold.
The concern is that all the clinical studies are based on short-term data. What happens after taking these drugs for a longer term?
To cause cancer, it will require time. You cannot get cancer in a short a few years. It may require many more years of development.
Therefore, if a safety conclusion is based on a short-term data, it is likely false information.
After a long-term use of estrogen, many women get breast, ovarian, and/or uterine cancers, especially the estrogen receptor sensitive breast cancer. You can find this out by just asking cancer survivors.
At this time there are more than 3.8 million breast cancer survivors in the United States. You may find them in your family, relatives, neighborhood, or even in this group.
Therefore, we need to be cautious when we see a news report that claims that a certain type of estrogen is safe. We need to check it out to see if it is false information.
About the safety of any treatment product, it is important to identify false information and make a well informed decision.
Feb 24, 2024

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