Are NeuEve products supported by clinical studies?

NeuEve is a natural product, not a drug, and has not been evaluated by the FDA. Therefore, we do not publish clinical trial data in the same manner as pharmaceutical products.

However, our formulations are developed based on well-established scientific principles, peer-reviewed research on the ingredients we use, and extensive customer experience over more than
10 years.

You can find summaries of relevant scientific studies on the ingredients (such as natural oils, vitamins, plant extracts, and nutrients) on our website. For your convenience, we have included references to the published literature below, although these are not specifically clinical trials of NeuEve.

A. Published literature on key ingredients used in NeuEve:

These published studies support the science behind NeuEve’s approach.

If one good ingredient could do the job, why use many? Because no single ingredient works perfectly on its own. Take lemon juice as an example. It’s rich in vitamin C and citric acid, both beneficial for women’s vaginal health. However, its acidity is extremely high (around pH 2), which can cause irritation or burning easily. By blending it with multiple other, less acidic ingredients, we can balance its strength: the acidity is softened, potential side effects are minimized, and the benefits of all ingredients are preserved. That’s why a combination of ingredients often works better. It retains the benefits while minimizing potential irritation or imbalance.

B. Third-Party Customer Survey Study

Typeform, a reputable third-party survey company trusted by brands like Apple, Airbnb, Uber, and Nike, conducted an extensive survey of NeuEve users. One month after purchasing a NeuEve product, participants received an email requesting feedback. The survey asked them to rate the severity of their symptoms before and after using NeuEve, with options ranging from very severe to no symptoms. Based on responses, Typeform generated charts to display customer feedback.

Survey Results:

1. Products for relieving vaginal dryness, atrophy, and BV

These products include NeuEve Velvet, Silk, Silver, and Gold suppositories, Salve and Salve-Gentle balms, and Feminine Moisture Support pills. These products are designed to relieve vaginal dryness and atrophy, but Silk, Silver, and Gold suppositories can also clear BV for women of different age groups. The results are all highly significant.

  • NeuEve Velvet (Sensitive Silk) (Recommended for Ages Over 70)
    • Participants: N = 53
    • Before Treatment: 22.6% very severe, 52.8% severe, 24.5% moderate, 0.0% slight, 0.0% no symptoms
    • After Treatment: 5.7% very severe, 17.0% severe, 32.1% moderate, 30.2% slight, 15.1% no symptoms
    • Statistical Analysis: Chi-squared value = 39.63, P-value = 5.16e-08 (highly significant)

Velvet Effect Chart.JPG

  • NeuEve Silk (Recommended for Ages 55-70)
    • Participants: N = 1,995
    • Before Treatment: 22.9% very severe, 45.4% severe, 28.3% moderate, 2.4% slight, 1.0% no symptoms
    • After Treatment: 3.5% very severe, 14.1% severe, 30.7% moderate, 36.8% slight, 14.9% no symptoms
    • Statistical Analysis: Chi-squared value = 1,459.51, P-value < 0.001 (highly significant)

Silk Effect Chart.JPG

  • NeuEve Silver (Recommended for Ages 45-55)
    • Participants: N = 532
    • Before Treatment: 16.5% very severe, 43.0% severe, 35.5% moderate, 3.6% slight, 1.5% no symptoms
    • After Treatment: 1.5% very severe, 8.5% severe, 25.4% moderate, 45.9% slight, 18.8% no symptoms
    • Statistical Analysis: Chi-squared value = 469.1, P-value = 3.22e-100 (highly significant)

(Note: The value 3.22e-100 represents 3.22 × 10^-100, which is scientific notation for a very small number. Specifically, it means: 3.22 is multiplied by 10 raised to the power of -100. This is an extremely small number, so small that it is practically close to zero.
In the context of statistical analysis, such a small p-value (close to 0) indicates extremely strong evidence against the null hypothesis. In simpler terms, it suggests that the observed results are highly statistically significant, meaning there is a very low probability that the observed outcome is due to random chance.)

Silver Effect Chart.JPG

  • NeuEve Gold (Recommended for Ages Under 45)
    • Participants: N = 259
    • Before Treatment: 20.1% very severe, 39.0% severe, 35.9% moderate, 4.6% slight, 0.4% no symptoms
    • After Treatment: 2.7% very severe, 6.2% severe, 20.8% moderate, 42.5% slight, 27.8% no symptoms
    • Statistical Analysis: Chi-squared value = 254.39, P-value = 7.36e-54 (highly significant)

Gold Effect Chart.JPG

  • NeuEve Vulva Balm Cream (Recommended for Ages Under 70)
    • Participants: N = 182
    • Before Treatment: 21.3% very severe, 43.5% severe, 30.0% moderate, 3.4% slight, 1.6% no symptoms
    • After Treatment: 2.0% very severe, 11.2% severe, 30.2% moderate, 41.2% slight, 15.4% no symptoms
    • Statistical Analysis: Chi-squared value = 1,052.73, P-value = 1.33e-226 (highly significant)

Salve chart.JPG

  • NeuEve Salve-Gentle (Sensitive Balm Cream) (Recommended for Ages Over 70)
    • Participants: N = 44
    • Before Treatment: 27.3% very severe, 47.7% severe, 20.5% moderate, 4.5% slight, 0.0% no symptoms
    • After Treatment: 4.5% very severe, 13.6% severe, 29.5% moderate, 38.6% slight, 13.6% no symptoms
    • Statistical Analysis: Chi-squared value = 34.11, P-value = 7.09e-07 (highly significant)

Salve-Gentle Chart.JPG

  • NeuEve Feminine Moisture Support (Sea Buckthorn Oil)
    • Participants: N = 182
    • Before Treatment: 23.1% very severe, 40.1% severe, 33.0% moderate, 3.3% slight, 0.5% no symptoms
    • After Treatment: 3.3% very severe, 10.4% severe, 34.6% moderate, 35.2% slight, 16.5% no symptoms
    • Statistical Analysis: Chi-squared value = 142.50, P-value = 8.21e-30 (highly significant)

FMS Effect Chart.JPG

2. Products for clearing stubborn BV and AV

These products include BV Clear and AV Clear (AV NIL). Their effects are all highly significant.

  • NeuEve BV Clear (Recommended for Ages Under 45) - Odor
    • Participants: N = 253
    • Before Treatment: 8.3% very severe, 23.3% severe, 33.2% moderate, 21.7% slight, 13.4% no odor
    • After Treatment: 2.0% very severe, 8.3% severe, 16.6% moderate, 25.7% slight, 47.4% no odor
    • Statistical Analysis: Chi-squared value = 90.72, P-value = 9.26e-19 (highly significant)

BV Clear on odor effect chart.JPG

  • NeuEve BV Clear (Recommended for Ages Under 45) - Discharge
    • Participants: N = 253
    • Before Treatment: 4.3% very severe, 11.1% severe, 41.1% moderate, 31.6% slight, 11.9% no discharge
    • After Treatment: 1.6% very severe, 5.5% severe, 21.7% moderate, 36.0% slight, 35.2% no discharge
    • Statistical Analysis: Chi-squared value = 52.95, P-value = 8.71e-11 (highly significant)

BV Clear on discharge effect chart.JPG

  • NeuEve BV Clear (Recommended for Ages Under 45) - Itching/burning
    • Participants: N = 253
    • Before Treatment: 8.7% very severe, 9.9% severe, 21.7% moderate, 20.2% slight, 39.5.9% no itching/burning
    • After Treatment: 5.1% very severe, 4.7% severe, 9.9% moderate, 22.1% slight, 58.1% no itching/burning
    • Statistical Analysis: Chi-squared value = 27.39, P-value = 1.65 × 10⁻⁵ (highly significant)

BV Clear on itching and burning effect chart.JPG

  • NeuEve AV NIL
    • Participants: N = 18
    • Before Treatment: 44.4% very severe, 38.9% severe, 11.1% moderate, 5.6% slight, 0.0% no symptoms
    • After Treatment: 5.6% very severe, 5.6% severe, 22.2% moderate, 38.9% slight, 27.8% no symptoms
    • Statistical Analysis: Chi-squared value = 20.06, P-value = 0.00049 (highly significant)

AV Clear Effect Chart.JPG

3. Summary:

The survey data are collected after one month of NeuEve use. The data might not fully reflect the true effect of the products. For example, for milder cases, users might experience improvement immediately or shortly after using the products, and one month would be too long for them. However, for severe cases, they may need a longer time to heal, and one month would be too short. Nonetheless, with continued application, all customers—including those with severe vaginal dryness from pelvic radiation or superbug infections unresponsive to estrogen or antibiotics—found full relief. One user of AV Clear (AV NIL) is a physician who has a severe case of AV (aerobic vaginitis) and has used 19 different antibiotics, but all have failed to provide relief. With only two packs of AV NIL, she found relief. Now it has been two years, and she is still AV-free.  These results confirm NeuEve’s effectiveness in alleviating vaginal dryness and restoring microbial balance.

C. How fast does NeuEve work?

To evaluate how fast NeuEve works, we conducted two survey studies.

1. BV clearance with BV Clear

A total of 98 customers participated in the survey. Among them, 25 had a single episode of BV, while 73 had recurrent BV. In the survey, we asked if they felt a significant improvement in 2 hours, 1 day, 4 days, and 7 days. The result is shown below:

How fast BV Claer Works.png

The result showed that 17% reported relief within 2 hours for both first and recurrent BV cases; 75% of first-time BV and 60% recurrent BV found relief within 1 day; 96% first-time BV and 85% of recurrent BV found relief within 4 days. There was another 5% more found recovery among recurrent cases after 7 days of treatment. There were 4% of new cases and 10% of recurrent cases that did not report significant relief after using BV Clear. To address these stubborn BV cases, we developed an extra-strength BV care product, BV Clear Finisher. It cleared all the stubborn BV cases.

2. Vaginal dryness, atrophy, and painful sex relief with NeuEve Silk and Salve

A total of 267 customers participated in this survey. Their ages spanned from 39 to 77, with the average age at 60. All reported having vaginal dryness and painful sex before using NeuEve. In the survey, we asked if they felt a significant improvement after using NeuEve for 7, 30, 90, and 180 days. The result is shown below:

How fast does NeuEve work.png

The result showed that 32% reported relief within 7 days; 78% found relief within 30 days; 87% found relief within 90 days; and 92% found relief within 180 days. The remaining 8% severe cases who did not find relief by using NeuEve suppositories and Salve alone were advised to add dilator exercises and dietary supplements. These stubborn cases all found relief shortly after used the combinational approach. This combinational approach is detailed in this article: I have painful sex. Can I use NeuEve to find relief quickly? Good for all ages.

Pelvic radiation therapy often results in the most severe vaginal atrophy due to its tissue-damaging effects. In such cases, both estrogen and laser treatments have failed to help. However, physicians at the renowned Massachusetts General Hospital (Harvard University, Boston) observed that NeuEve provided significant, lasting relief for their radiation-treated patients. As a result, NeuEve is now recognized as one of the most effective natural, hormone-free solutions for vaginal dryness and atrophy.

D. What other conditions can NeuEve help?

In addition to clearing BV and relieving painful sex, NeuEve offers unique products to relieve the following conditions that do not respond to standard treatments:

E. Further reading:

Oct 13, 2025

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